THE RSPCA and groups like ABC Rescue, Lucky Paws Rescue and Friends of the Hound will conduct the Big Adopt Out at the Brisbane Showgrounds on Saturday, September 14 from 9am to 2pm.
More than 300 cats, dogs, puppies and kittens will be looking for new homes, with animal rescue groups all working under the one roof.
In its seventh year, the Big Adopt Out showcases how rescue groups and the RSPCA work together to save lives.
RSPCA spokesman Michael Beatty said veterinary advice, pet services and products would be available to get new family members started on the right paw.
"This will be the largest variety of dogs and cats in one place at one time," he said.
"At the Big Adopt Out you'll get the very best information from people who understand the breeds and their needs. If you're thinking about adopting a new pet then this is the place to start."
RSPCA Queensland works with more than 100 rescue groups year-round, across Australia and scores of animals are rehomed through this partnership.
"Rescue groups are so important when it comes to dogs that need one-on-one attention," Mr Beatty said.
"They can give individual care and training until the dog is ready to be adopted.
"...If you are looking for a companion for your pre-existing dog, you can bring your dog along to the event.
"There will be a dog minding area where Paws and Relax will take care of your pooch while you browse for another canine companion. Then you can all have a meet and greet to see if they are a match."
Mr Beatty said when people rescued an animal, they were giving them the second chance they deserved and in return, owners received a lifetime of love, happiness and laughs.